François Diederich Selected Research

queuine tRNA-ribosyltransferase

1/2022	19F-NMR Unveils the Ligand-Induced Conformation of a Catalytically Inactive Twisted Homodimer of tRNA-Guanine Transglycosylase.
10/2021	Unraveling a Ligand-Induced Twist of a Homodimeric Enzyme by Pulsed Electron-Electron Double Resonance.
1/2020	Fragment Screening Hit Draws Attention to a Novel Transient Pocket Adjacent to the Recognition Site of the tRNA-Modifying Enzyme TGT.
1/2018	Swapping Interface Contacts in the Homodimeric tRNA-Guanine Transglycosylase: An Option for Functional Regulation.
1/2017	Soaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibition.
1/2015	Replacement of water molecules in a phosphate binding site by furanoside-appended lin-benzoguanine ligands of tRNA-guanine transglycosylase (TGT).
9/2013	High-affinity inhibitors of Zymomonas mobilis tRNA-guanine transglycosylase through convergent optimization.
1/2013	Launching spiking ligands into a protein-protein interface: a promising strategy to destabilize and break interface formation in a tRNA modifying enzyme.
12/2009	How to replace the residual solvation shell of polar active site residues to achieve nanomolar inhibition of tRNA-guanine transglycosylase.
10/2009	High-affinity inhibitors of tRNA-guanine transglycosylase replacing the function of a structural water cluster.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

François Diederich Research Topics

Disease

13	Bacillary Dysentery (Shigellosis) 01/2022 - 06/2008
5	African Trypanosomiasis (Nagana) 09/2019 - 11/2008
5	Malaria 07/2011 - 03/2006
4	Parkinson Disease (Parkinson's Disease) 05/2011 - 01/2003
3	Communicable Diseases (Infectious Diseases) 01/2017 - 08/2008
3	Foodborne Diseases 01/2015 - 07/2012
2	Chagas Disease (American Trypanosomiasis) 09/2019 - 11/2008
1	Leishmaniasis 09/2019
1	Parasitemia 01/2017
1	Neoplasms (Cancer) 08/2016
1	Tuberculosis (Tuberculoses) 01/2008
1	Infections 07/2007
1	Dysentery 07/2007
1	Skeletal Abnormalities Mandibular Hypoplasia Auditory Canal Atresia Short Stature 09/2005

Drug/Important Bio-Agent (IBA)

16	EnzymesIBA 01/2022 - 01/2003
12	queuine tRNA-ribosyltransferaseIBA 01/2022 - 06/2008
7	Pharmaceutical PreparationsIBA 01/2018 - 10/2009
4	Terpenes (Terpenoids)IBA 01/2017 - 01/2008
4	Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA 05/2011 - 01/2003
3	LigandsIBA 10/2021 - 03/2009
3	Transfer RNA (tRNA)IBA 01/2018 - 10/2009
3	Mevalonic Acid (Mevalonate)IBA 02/2014 - 01/2008
2	trypanothione reductaseIBA 09/2019 - 11/2008
2	rhodesainIBA 01/2018 - 06/2013
2	Cysteine Proteases (Cysteine Protease)IBA 01/2018 - 06/2013
2	HerbicidesIBA 01/2017 - 02/2014
2	Proteins (Proteins, Gene)FDA Link 07/2011 - 03/2009
2	Levodopa (L Dopa)FDA LinkGeneric 05/2011 - 06/2008
1	Ether (Diethyl Ether)IBA 01/2018
1	Glycine Hydroxymethyltransferase (Serine Hydroxymethyltransferase)IBA 08/2016
1	Antimalarials (Antimalarial Agents)IBA 08/2016
1	Doxorubicin (Adriamycin)FDA LinkGeneric 08/2016
1	Shiga Toxin (Shigella Toxin)IBA 07/2012
1	plasmepsin (plasmepsin I)IBA 07/2011
1	trypanothioneIBA 12/2009
1	Peptide Hydrolases (Proteases)FDA Link 03/2006
1	Neurotransmitter Agents (Neurotransmitter)IBA 03/2006
1	CatecholaminesIBA 03/2006
1	SolutionsIBA 09/2005
1	FullerenesIBA 09/2005

Therapy/Procedure

1	Drug Therapy (Chemotherapy) 01/2017
1	Electrodes (Electrode) 09/2005